Antibacterial Activity of Twenty Iranian Plant Extracts Against Clinical Isolates of Helicobacter pylori

Authors

  • Farahnaz Nariman Department of Biology and Microbiology, Faculty of Sciences, Alzahra University, Tehran, Iran
  • Fereshteh Eftekhar Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, G.C., Tehran, Iran
  • Reza Malekzadeh Digestive Diseases Research Center, Faculty of Medical Sciences, Tehran University, Tehran, Iran
  • Sadegh Massarrat Digestive Diseases Research Center, Faculty of Medical Sciences, Tehran University, Tehran, Iran
  • Zohreh Habibi Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, G.C., Tehran, Iran
Abstract:

Objective(s) Due to increasing emergence of drug-resistance in Helicobacter pylori isolates, traditional plants are potentially valuable sources of novel anti-H. pylori agents. In this research, anti-H. pylori activity of the organic extracts of twenty native Iranian plants was determined against ten clinical isolates of H. pylori. Materials and Methods Disc diffusion was used to determine the biological activity of 20 plant extracts as well as 8 antibiotics commonly used to treat H. pylori infections. Minimum inhibitory concentrations were also measured by tube and agar dilution methods for the biologically active plant extracts. Results Of the twenty plant extracts analyzed, sixteen exhibited good anti-H. pylori activity, using disc diffusion. The ten most active extracts were Carum bulbocastanum, Carum carvi, Mentha longifolia, Saliva limbata, Saliva sclarea, Ziziphora clinopodioides, Thymus caramanicus, Glycyrrhiza glabra, Xanthium brasilicum and Trachyspermum copticum. Minimum inhibitory concentrations measured for the 10 biologically active plant extracts were within the range of 31.25 to 500 ^g/ml. Conclusion Among the ten plant extracts effective against H. pylori clinical isolates, Carum carvi, Xanthium brasilicum and Trachyspermum copticum showed the highest activity.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

antibacterial activity of twenty iranian plant extracts against clinical isolates of helicobacter pylori

objective(s) due to increasing emergence of drug-resistance in helicobacter pylori isolates, traditional plants are potentially valuable sources of novel anti-h. pylori agents. in this research, anti-h. pylori activity of the organic extracts of twenty native iranian plants was determined against ten clinical isolates of h. pylori. materials and methods disc diffusion was used to determine the ...

full text

Antibacterial activities of Galla rhois extracts against Helicobacter pylori infection

In this study, a medicinal plant, Galla rhois (GR), was examined and screened for its anti-Helicobacter pylori activity. Galla rhois was extracted with 70% ethanol. Inhibitory zone tests, as in vitro assays, and an in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. The safety of the GR extract was then evaluated in an animal study. The Galla rhois extract demon...

full text

Antibacterial activities of Galla rhois extracts against Helicobacter pylori infection

In this study, a medicinal plant, Galla rhois (GR), was examined and screened for its anti-Helicobacter pylori activity. Galla rhois was extracted with 70% ethanol. Inhibitory zone tests, as in vitro assays, and an in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. The safety of the GR extract was then evaluated in an animal study. The Galla rhois extract demon...

full text

Pectin shows antibacterial activity against Helicobacter pylori

Pectins are the collective name for a group of heterogeneous, high molecular weight, branched polysaccharides that are found in the cell walls of higher plants. In this study, we intend to determine the antibacterial activity of pectin against reference strains and clinical isolates of Helicobacter pylori. The results show that pectin produced antibacterial effects on all the 16 clinical isolat...

full text

[Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba].

Four known compounds have been isolated from the aerial parts of the Brazilian medicinal plant Pariparoba (Pothomorphe umbellata). They were an alkaloid, a flavone, a dihydrocalcone, and a steroid. The chemical structures were established to be N-benzoylmescaline, wogonin, uvangoletin, and beta-sitosterol glucoside using spectral methods. Among these compounds, the main component N-benzoylmesca...

full text

Antibacterial activity of lactobacilli probiotics on clinical strains of Helicobacter pylori

Objective(s): Treatment of Helicobacter pylori infection by common drugs may be associated with several problems such as antimicrobial resistance to commonly used antibiotics and side effects of employed drugs. Therefore, exploration of non-chemical compounds which are safer than chemical ones is becoming important as an alternative therapy. The purpose of this study w...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 12  issue 2

pages  105- 111

publication date 2009-04-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023